Genomics trumps clinical criteria in BMT? Nyet!

ICRP comes up trumps.

Haplo-BMT: which approach?

In patients with hematologic malignancies, Di Bartolomeo et al report encouraging outcomes after transplantation of granulocyte-colony stimulating factor (G-CSF)– primed unmanipulated bone marrow from human leukocyte antigen (HLA)– haplotype mismatched (haploidentical) related donors, suggesting that this procedure makes haploidentical transplantation available in all transplant centers.

Policy trumps science in the Bush administration.

Not long ago, a group of more than 60 top United States scientists, including more than 20 past Nobel laureates and past scientific advisors to Republican administrations, accused the Bush administration of manipulating and censoring science for political purposes.1 Included among those involved were David Baltimore, Paul Ehrlich, Leon Lederman, E.O. Wilson and Harold Varmus. The charges are qu...

Acidotoxicity trumps excitotoxicity in ischemic brain.

This question remains incompletely answered 2 decades later, during which excitatory amino acids and calcium toxicity have been central research and therapeutic targets. Recently, attention has returned to a central neurochemical feature of ischemic brain injury, acidosis, which was focused on in Plum’s lecture. Targeting this effector of injury as therapy for brain ischemia now may be closer a...

When equality trumps reciprocity

Abstract: Inequity aversion and reciprocity have been identified as two primary motivations underlying human decision making. However, because income and wealth inequality exist to some degree in all societies, these two key motivations can point to different decisions. In particular, when a beneficiary is less wealthy than a benefactor, a reciprocal action can lead to greater inequality. In th...